Hi there, "FriFlo", and Welcome back to the forum!

A rather late welcome, but better late than never! Been a bit busy here on the forum lately, and I only just noticed that nobody had replied to your post.
Anyway...
This is my original plan for my 5.1 system of adam p22a with LCR soffit mounted:
It is possible to mount two sets of speakers in one set of soffits, but you do have to be careful: there are limits to what will work. Yes, you can tilt part of the soffit to do it, but you should never go beyond 10° of tilt, and some of us think that even 10° is too much, and 7° should be the limit (for rather complex reasons, to do with the way the human ear works, and how it identifies direction). I'm not sure what angles you are tilting at, but the look like they are more than 7°.
Also, the way you show your P22's is not correct. The beveled edges need to be sunk into the soffit, so that the front fave of the speaker is flush with the soffit all around. That means that you need a strange shaped and unusually angled hoe cut in the soffit panel, to mimic the shape of the beveling on the P22A, but it is the only way to do it correctly.
My only concern is the flat area where each monitor is mounted is way smaller than in the original layout and this is the very reason for soffit mounting: creating an "endless front" for the monitors.
"Infinite baffle" is the technical term, but yes, that's the correct concept. However, you actually are doing that, since all three soffits will be solid, hard, flat rigid surfaces that meet, so each soffit is a sort of extension of the one next to it. As long as you blend the L and R soffits into the room side walls, you should be OK. There seems to be enough area around each individual speaker, and the adjacent surfaces will do the rest of the job, albeit not perfectly.
I have not found many examples of people soffit mounting multiple stereo pairs. Surely, there must be a reason for this.
Yep! The reason is that it is dam hard to get it all done right! It can be done.
- on axis and same distance for two stereo pairs (plus the option of a third one on the meterbridge)
I'd skip the "third one on the meterbridge" part: that's never a good idea, even though you see it so very often, and even in studios that should know better!
Any input appreciated!
One thing I did notice is your aim points are slightly off. Yes, I know that that's how EBU shows it, but in reality most people have their ears mounted on the sides of their heads, not the center of their brains, or in their eyeballs, so it is better to adjust those speaker locations slightly such that the acoustic axes of the speakers are aimed at your ears!

Make a sphere about the size of your head, and position it so that the equator is 1.2 m above the floor, centered on the theoretical EBU circle. Now re-aim the L, R and surround speakers so that the axes graze just past the edge of the sphere, maybe a cm or so away. The axes from the L and R speakers will intersect about 25 to 30 cm behind your head, and the axes from the surrounds will intersect a few cm in front of your nose. That's the correct way to do it, and gives you a better sweet spot.
What about the distance between monitors (the o300 pair) and ceiling? Is it to close? Is there some kind of margin, how close it my get?
It's not so much the distance, as the first reflections. It looks like you might have a problem there with reflections off the ceiling getting to your ears. There's also not much space up there for a cloud.
- Stuart -