Minimizing the interference of immovable support columns

I've spent some time trying to find an answer to this question -- forgive me if its hanging out here somewhere under different terminology. If I have a live room of roughly 850 square feet, and there are 4 immovable support columns distributed fairly evenly throughout that space, how negatively does that impact the acoustics of the room? How much can that be offset by adding diffusion and / or absorption around it? Thanks!

What type of columns? How big? They most likely won't make a big difference to acoustics, but they might (if they are large, they could be causing reflections, for example). But they could be making a difference to your isolation: they might be flanking noise either into or out of your room, or both. Photos might be useful to help figure this out! Do you suspect that you have acoustic problems in the room? Does it sound bad in there? Can you describe what it sounds like? Better yet, download REW and run an analysis on the room, to see where the issues are. - Stuart -

Also shape. A round (cylindric) column will be more diffusive by nature as opposed to a square column. As Stuart said - Photos!