So, if i varied slot and slat width across my entire back wall i could target all my lowest modes very effectively.
You can target a broad range of frequencies like that, yes. You can also vary the depth, by having one end of the cavity deeper than than other. However, there's a couple of other issues to take into account:
1) It's really hard to target modal frequencies with slat walls: the slot (gap between slats) has to become very small, and/or the depth has to become very large, and/or the size of the slat (height, or thickness) has to become very large, in order to get down to those low frequencies.
2) Also, it's notoriously hard to tune a Helmholtz resonator precisely to hit the mode exactly. Modes are very high Q: very narrow bandwidth, just a few Hz wide at best. Helmholtz resonators are very high Q: also just a few Hz bandwidth. So lining up those two Q peaks is a real challenge. Yes, you can reduce the Q of the device by tuning it more broadly, but that reduces efficiency, even though it will hit the target frequency better.
3) You need a very large internal volume to effectively deal with a mode. Some research suggest that you need at least 1% of the room volume to do that. So if you have to hit 6 modes, you'd need 6% of your room taken up by such devices. In a small room, that usually isn't feasible.
4) The dimensions of the device vs. the wavelength: The equations are only valid for the case where the device is considerably smaller than the wavelength being treated.
5) Open area: If the relationship between the total area of the slots an the total area of the slats+slots is large, (greater than about 20 to 30%), then the device acts mostly as a broadband absorber. If the open area is less than about 5 to 10%, then it acts as an array of individual resonators, each tuned to its own frequency.
Etc.
Lots of stuff to take into account with Helmholtz devices. Here's a link to a room that is in the process of being tuned right now, where you can see all of this theory in action, and how it works out in the real world:
http://www.johnlsayers.com/phpBB2/viewt ... 68&start=0 You can see a couple of different types of Helmholtz device in there, and see the effect they have on a room.
Would there be a downside to doing that vs leaving the entire wall as a porus absorber or a slat absorber with a mls sequence? Or would it be better to do a mixture?
It depends on what the room needs!

Slot resonators are very useful devices, but hard to tune, and I generally only use them for stubborn issues that aren't responding well to other treatment, or where I can get plenty of "bang for the buck" by combing several devices into one, as was the case with that room.
- Stuart -